What is LGD-4033?
Developed by Ligand Pharmaceuticals.
LGD-4033 is a selective androgen receptor modulator. It is tissue selective, developed to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss. LGD-4033 is expected to produce the therapeutic benefits of testosterone with improved safety, tolerability and patient acceptance due to tissue-selective mechanism of action and an oral route of administration.
How it works
LGD-4033, a nonsteroidal, oral SARM, selects bones and muscles versus organs such as prostate. LGD-4033 has completed a Phase I Multiple Ascending Dose study in healthy volunteers. This randomized, double-blind, placebo-controlled Phase I study established the safety and tolerability up to doses of 22 mg per day.
LGD-4033 has undergone several recent studies and trials to find the best and safest way to use it. From these trials, the results have shown increases in lean body mass and decreases in body fat. There is also a significant increase in strength, well-being, as well as healing possibilities.
LGD has shown the most ability of any SARM to put on size that could be considered a bulk. This will, of course, be dependent upon the diet used. (Increased calories) 10-15 lbs. possible gain.
LGD seems to do very well with this method. Many have seen an increase in lean body mass and a decrease in body fat. LGD seems to work the best with this method.
LGD can be used to cut as well. (Calorie dependent)
Through studies and logs, the side effects from LGD have so far shown to be minimal. The suppression shown has been dose dependent, but there has been a decrease in total and free testosterone as well as SHBG. This is very encouraging to users as it shows that while suppressive, recovery will still not be near as long as with anabolic steroids. It has not shown increases in estradiol, but, as with anything, an aromatase inhibitor should be kept on hand.
A full pct, as opposed to a mini pct with other SARMS, is recommended after a cycle of LGD. While it may not be quite as suppressive as anabolics, the suppression is much higher than other SARMS, thus, requiring a full PCT.
My Experience With LGD
When I first ran a cycle with LGD, the first thing I noticed was incredible strength increases, fantastic pumps and unfortunately cramps! I would highly recommend using Taurine and a quality electrolyte supplement if you are anything like myself. I cramped really bad and at the time I didn’t know much about how to fix it.
I believe that I gained 5 lbs of muscle my first run with it, not much to speak of afterwards; as I have explained before, I believe that SARMs are fantastic but I believe that they definitely have their limits in the amount of size that you can put on.
LGD is very suppressive to some (especially us older guys) I would recommend using some 4 andro as a testosterone base or if you are on Testosterone Replacement Therapy, that will do great. If you are getting super tired, sex drive is down and generally feeling like crap – that is suppression. Having something like a 4 andro will help substantially.